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  1. Alzheimer's disease, known to be associated with the gradual loss of memory, is characterized by low concentration of acetylcholine in the hippocampus and cortex part of the brain. Inhibition of acetylcholines...

    Authors: Zaheer Ul-Haq, Waqasuddin Khan, Saima Kalsoom and Farzana L Ansari

    Citation: Theoretical Biology and Medical Modelling 2010 7:22

    Content type: Research

    Published on:

  2. In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells gro...

    Authors: Mitra S Feizabadi and Tarynn M Witten

    Citation: Theoretical Biology and Medical Modelling 2010 7:21

    Content type: Research

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  4. According to the hypothesis explored in this paper, native aggregation is genetically controlled (programmed) reversible aggregation that occurs when interacting proteins form new temporary structures through ...

    Authors: Vladimir V Matveev

    Citation: Theoretical Biology and Medical Modelling 2010 7:19

    Content type: Review

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  5. ChIP-Seq is a powerful tool for identifying the interaction between genomic regulators and their bound DNAs, especially for locating transcription factor binding sites. However, high cost and high rate of fals...

    Authors: Song Wu, Jianmin Wang, Wei Zhao, Stanley Pounds and Cheng Cheng

    Citation: Theoretical Biology and Medical Modelling 2010 7:18

    Content type: Research

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  6. Humans are routinely and concurrently exposed to multiple toxic chemicals, including various metals and organics, often at levels that can cause adverse and potentially synergistic effects. However, toxicokine...

    Authors: Alan F Sasso, Sastry S Isukapalli and Panos G Georgopoulos

    Citation: Theoretical Biology and Medical Modelling 2010 7:17

    Content type: Research

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  7. Glucocorticoids (GC) represent the core treatment modality for many inflammatory diseases. Its mode of action is difficult to grasp, not least because it includes direct modulation of many components of the ex...

    Authors: Uwe Klinge, Nicolette Farman and Anette Fiebeler

    Citation: Theoretical Biology and Medical Modelling 2010 7:16

    Content type: Research

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  9. Although the prognosis for Lupus Nephritis (LN) has dramatically improved with aggressive immunosuppressive therapies, these drugs carry significant side effects. To improve the effectiveness of these drugs, b...

    Authors: Paula Budu-Grajdeanu, Richard C Schugart, Avner Friedman, Daniel J Birmingham and Brad H Rovin

    Citation: Theoretical Biology and Medical Modelling 2010 7:14

    Content type: Research

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  10. In many areas of medical research, a bivariate analysis is desirable because it simultaneously tests two response variables that are of equal interest and importance in two populations. Several parametric and ...

    Authors: Hamed Tabesh, S MT Ayatollahi and Mina Towhidi

    Citation: Theoretical Biology and Medical Modelling 2010 7:13

    Content type: Research

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  11. Experimental reality in molecular and cell biology, as revealed by advanced research technologies and methods, is manifestly inconsistent with the design perspective on the cell, thus creating an apparent para...

    Authors: Alexei Kurakin

    Citation: Theoretical Biology and Medical Modelling 2010 7:12

    Content type: Review

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  13. It is reasonable to consider the thalamus a primary candidate for the location of consciousness, given that the thalamus has been referred to as the gateway of nearly all sensory inputs to the corresponding co...

    Authors: Byoung-Kyong Min

    Citation: Theoretical Biology and Medical Modelling 2010 7:10

    Content type: Research

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  14. The Minimal Model, (MM), used to assess insulin sensitivity (IS) from Intra-Venous Glucose-Tolerance Test (IVGTT) data, suffers from frequent lack of identifiability (parameter estimates with Coefficients of V...

    Authors: Simona Panunzi, Andrea De Gaetano and Geltrude Mingrone

    Citation: Theoretical Biology and Medical Modelling 2010 7:9

    Content type: Research

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  15. A tendency to develop reentry orthostasis after a prolonged exposure to microgravity is a common problem among astronauts. The problem is 5 times more prevalent in female astronauts as compared to their male c...

    Authors: Richard L Summers, Steven Platts, Jerry G Myers and Thomas G Coleman

    Citation: Theoretical Biology and Medical Modelling 2010 7:8

    Content type: Research

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  16. Signal transduction networks represent the information processing systems that dictate which dynamical regimes of biochemical activity can be accessible to a cell under certain circumstances. One of the major ...

    Authors: Jayson Gutiérrez, Georges St Laurent III and Silvio Urcuqui-Inchima

    Citation: Theoretical Biology and Medical Modelling 2010 7:7

    Content type: Research

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  18. The order retroviridae comprises viruses based on ribonucleic acids (RNA). Some, such as HIV and HTLV, are human pathogens. Newly emerged human retroviruses have zoonotic origins. As far as has been establishe...

    Authors: Misaki Wayengera

    Citation: Theoretical Biology and Medical Modelling 2010 7:5

    Content type: Database

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  20. The robust storage, updating and utilization of information are necessary for the maintenance and perpetuation of dynamic systems. These systems can exist as constructs of metal-oxide semiconductors and silico...

    Authors: David J D'Onofrio and Gary An

    Citation: Theoretical Biology and Medical Modelling 2010 7:3

    Content type: Review

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  22. In many parts of the world, the exponential growth rate of infections during the initial epidemic phase has been used to make statistical inferences on the reproduction number, R, a summary measure of the transmi...

    Authors: Hiroshi Nishiura, Gerardo Chowell, Muntaser Safan and Carlos Castillo-Chavez

    Citation: Theoretical Biology and Medical Modelling 2010 7:1

    Content type: Commentary

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  25. After our work was published, we found that some of the terms in the equations were incorrect and that there were some typographical errors in the abbreviations.

    Authors: Hirotaka Ando, Shigeru Izawa, Wataru Hori and Ippei Nakagawa

    Citation: Theoretical Biology and Medical Modelling 2009 6:29

    Content type: Erratum

    Published on:

    The original article was published in Theoretical Biology and Medical Modelling 2008 5:19

  26. In silico techniques are highly suited for both the discovery of new and development of existing vaccines. Enterohemorrhagic Escherichia coli O157:H7 (EHEC) exhibits a pattern of localized adherence to host cells...

    Authors: Jafar Amani, S Latif Mousavi, Sima Rafati and Ali H Salmanian

    Citation: Theoretical Biology and Medical Modelling 2009 6:28

    Content type: Research

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  27. Mere possibility is not an adequate basis for asserting scientific plausibility. A precisely defined universal bound is needed beyond which the assertion of plausibility, particularly in life-origin models, can b...

    Authors: David L Abel

    Citation: Theoretical Biology and Medical Modelling 2009 6:27

    Content type: Research

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  28. The physiological fact that a stable level of brain glucose is more important than that of blood glucose suggests that the ultimate goal of the glucose-insulin-glucagon (GIG) regulatory system may be homeostas...

    Authors: Lu Gaohua and Hidenori Kimura

    Citation: Theoretical Biology and Medical Modelling 2009 6:26

    Content type: Research

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  30. Phytophthora infestans is a devastating oomycete pathogen of potato production worldwide. This review explores the use of computational models for studying the molecular interactions between P. infestans and one ...

    Authors: Andrés Pinzón, Emiliano Barreto, Adriana Bernal, Luke Achenie, Andres F González Barrios, Raúl Isea and Silvia Restrepo

    Citation: Theoretical Biology and Medical Modelling 2009 6:24

    Content type: Review

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  31. The formal kinetics of the H1N1 epidemic seems to take the form of an exponential curve. There is a good correlation between this theoretical model and epidemiological data on the number of H1N1-infected peopl...

    Authors: Konstantin G Gurevich

    Citation: Theoretical Biology and Medical Modelling 2009 6:23

    Content type: Commentary

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  32. The filamentous fungus Moniliophthora perniciosa (Stahel) Aime & Phillips-Mora is a hemibiotrophic Basidiomycota that causes witches' broom disease of cocoa (Theobroma cacao L.). This disease has resulted in a se...

    Authors: Bruno S Andrade, Alex G Taranto, Aristóteles Góes-Neto and Angelo A Duarte

    Citation: Theoretical Biology and Medical Modelling 2009 6:22

    Content type: Research

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  35. The scheme of the core vestibular membranes, consisting of serially connected utricle, ampulla and semicircular canal, first appeared hundreds of millions of years ago in primitive fish and has remained largel...

    Authors: Daniel J Pender

    Citation: Theoretical Biology and Medical Modelling 2009 6:19

    Content type: Research

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  36. Polycystic ovary syndrome (PCOS) is a complex but frequently occurring endocrine abnormality. PCOS has become one of the leading causes of oligo-ovulatory infertility among premenopausal women. The definition ...

    Authors: Zeti-Azura Mohamed-Hussein and Sarahani Harun

    Citation: Theoretical Biology and Medical Modelling 2009 6:18

    Content type: Research

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  39. Cardiac tamponade is a condition whereby fluid accumulation in the pericardial sac surrounding the heart causes elevation and equilibration of pericardial and cardiac chamber pressures, reduced cardiac output,...

    Authors: Deepa Ramachandran, Chuan Luo, Tony S Ma and John W Clark Jr

    Citation: Theoretical Biology and Medical Modelling 2009 6:15

    Content type: Research

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  40. Mosquitoes are the transmissive vectors for several infectious pathogens that affect man. However, the control of mosquitoes through insecticide and pesticide spraying has proved difficult in the past. We hypo...

    Authors: Wilson Byarugaba, Henry Kajumbula and Misaki Wayengera

    Citation: Theoretical Biology and Medical Modelling 2009 6:14

    Content type: Research

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  41. Recent experiments have explored effects of activities of kinases other than the well-studied GSK3β, in wnt pathway signaling, particularly at the level of β-catenin. It has also been found that the kinase PKA...

    Authors: Ying-Chieh Sun

    Citation: Theoretical Biology and Medical Modelling 2009 6:13

    Content type: Research

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  42. Rat models are frequently used to find genomic regions that contribute to complex diseases, so called quantitative trait loci (QTLs). In general, the genomic regions found to be associated with a quantitative ...

    Authors: Lars Andersson, Greta Petersen and Fredrik Ståhl

    Citation: Theoretical Biology and Medical Modelling 2009 6:12

    Content type: Research

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  46. When grown in three-dimensional (3D) cultures, epithelial cells typically form cystic organoids that recapitulate cardinal features of in vivo epithelial structures. Characterizing essential cell actions and t...

    Authors: Sean HJ Kim, Sunwoo Park, Keith Mostov, Jayanta Debnath and C Anthony Hunt

    Citation: Theoretical Biology and Medical Modelling 2009 6:8

    Content type: Research

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  50. In vitro culture of pathogens on growth media forms a "pillar" for both infectious disease diagnosis and drug sensitivity profiling. Conventional cultures of Mycobacterium tuberculosis (M.tb) on Lowenstein Jensen...

    Authors: Misaki Wayengera

    Citation: Theoretical Biology and Medical Modelling 2009 6:4

    Content type: Database

    Published on:

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682