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Process
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Nodes in the
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Experimental markers
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Validated role
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References
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FA/BRCA BNM
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used in this study
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in the BNM
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DNA damage
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ICL
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MMC
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FA cells are
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[21, 25, 26]
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induction
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hypersensitive
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to ICL inducing
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agents
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Upstream
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FAcore
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Non-evaluated
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ICL recognition
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[14, 16, 17]
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FA/BRCA
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FANCD2I
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proteins
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pathway
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NUC1
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NUC2
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DNA repair
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ADD
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γH2AX,
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ICLs are unhooked
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[13, 21]
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intermediaries
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DSB
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CA in metaphase
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by FA core-recruited
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spreads
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DNA-endonucleases
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that generate a DSB
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and an ADD
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Downstream
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TLS
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Non-evaluated
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The ADD and DSB
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[14, 15, 18, 54]
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FA/BRCA
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FAHRR
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are repaired by TLS
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pathway
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and FA-dependent
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downstream homologous
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recombination repair,
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respectively. FA cells
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accumulate DSBs
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Alternative
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HRR2
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Non-evaluated
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FA cells use
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[49, 56]
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DNA repair
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NHEJ
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alternative DNA
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pathways
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repair pathways,
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mainly NHEJ
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HRR2 is a
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criptic repair choice
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Checkpoint
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ATR
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Cell cycle arrest
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Upon DNA damage
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[27, 28, 31]
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ATM
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in G2, pCHK1-S341,
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normal and FA
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p53
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p21 gene expression,
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cells activate
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MYT1, WEE1, p21
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the G2/M checkpoint
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proteins
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Checkpoint
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CHKREC
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MPM2 mitotic index,
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The checkpoint
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[83, 84] and this work
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recovery
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cytokinesis block assay,
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is inactivated by
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G2/M transcriptional
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CHKREC after
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program, WIP1, PLK1,
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DNA repair
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CDC25, Aurora A
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FA cells seem to have
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proteins
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a lower threshold for
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CHKREC activation
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compared to normal cells
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