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Node in the
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Nodes in the
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Simplification criteria
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original BNM
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simplified BNM
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ICL
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ICL
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Unchanged node
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FANCM, FAcore
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FAcore
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ICL recognition proteins working
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together in the upstream FA/BRCA
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pathway
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FANCD2I
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FANCD2I
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Unchanged node
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MUS81
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NUC1
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Nuclease mediated
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ICL incision
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XPF, FAN1
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NUC2
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Nuclease mediated
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ICL incision
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ADD
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ADD
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Unchanged node
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DSB
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DSB
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Unchanged node
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ATR, CHK1, H2AX
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ATR
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These proteins act in the
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Checkpoint pathway
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ATM, CHK2, H2AX
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ATM
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These proteins act in the
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Checkpoint pathway
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p53
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p53
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Unchanged node
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PCNATLS
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TLS
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This is only a change in name
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FANCJMLH1, MRN, BRCA1,
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FAHRR
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These proteins act in the
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FANCD1N, RAD51, HRR,
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Homologous Recombination
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ssDNARPA
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Repair pathway
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——
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HRR2
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New node representing the
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alternative Homologous
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Recombination Repair Pathway
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KU, DNAPK, NHEJ
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NHEJ
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These proteins act in the
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Non-Homologous End-Joining
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DNA repair pathway
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USP1, CHKREC
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CHKREC
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Global negative regulators
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| | |
of the FA/BRCA pathway
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