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Table 1 Boolean functions for the nodes in the FA/BRCA network

From: Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process

RULES REFERENCES  
ICL ← ICL ¬ DSB [38]  
FAcore ← ICL (ATR ATM) ¬ CHKREC [14, 16, 4446]  
FANCD2I ← FAcore ((ATR ATM) ((ATR ATM) DSB)) [4749]  
¬ (CHKREC)   
NUC1 ←ICL FANCD2I [50]; [38]  
NUC2 ← (ICL (ATR ATM) ¬ (FAcore FANCD2I)) [51]; [38]  
(ICL NUC1 p53 ¬(FAcore FANCD2I))   
ADD ← (NUC1 NUC2 (NUC1 NUC2)) ¬ (TLS) [47, 50, 51]  
DSB ← (NUC1 NUC2) ¬ (NHEJ FAHRR HRR2) [50, 52]  
TLS ← (ADD (ADD FAcore)) ¬ (CHKREC) [53, 54]  
FAHRR ← DSB FANCD2I ¬ (NHEJ CHKREC) [53, 54]  
HRR2 ← (DSB NUC2 NHEJ ICL ¬ (FAHRR CHKREC)) [38]  
(DSB NUC2 TLS ¬ (NHEJ FAHRR CHKREC))   
NHEJ ← (DSB NUC2 ¬ (FAHRR HRR2 CHKREC)) [49, 52, 5557]  
ATR ←(ICL ATM) ¬ CHKREC [5860]  
ATM ← (ATR DSB) ¬ CHKREC FAcore [61, 62]  
P53 ← ((ATR ATM) NHEJ) ¬ CHKREC [58, 63, 64]  
CHKREC ← ((TLS NHEJ FAHRR HRR2) ¬ DSB) [52, 53];  
((¬ ADD) (¬ ICL) (¬ DSB) ¬ (CHKREC)) [38, 65]  
  1. Key references are included. Full discussion of interactions can be found in [38]