Figure 1

Overall schematic of interactions between tumor cells, neutrophils, platelets and endothelial cells within the ABMEM. Blue arrows represent binding interactions between cell surface receptors. Black arrows represent diffusion of released mediators. Red arrows represent inhibition of a cell-cell interaction. PMN = polymorphonuclear leukocyte (neutrophil), IL-8 = interleukin-8, NO = nitric oxide.